منابع مشابه
RNA-dependent RNA polymerases, viruses, and RNA silencing.
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA-dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing. Although the viral and cellular RdRps have no sequence homology, they share...
متن کامل1 Silencing Viruses by Rna Interference
Post-transcriptional gene silencing (PTGS) makes possible new approaches for studying the various steps of the viral cycle. Plus-strand RNA viruses appear to be attractive targets for small interfering RNAs (siRNAs), as their genome functions as both mRNA and replication template. PTGS creates an alternative to classic reverse genetics for viruses with either negative-strand or double-stranded ...
متن کاملMosquito-Borne Viruses and Suppressors of Invertebrate Antiviral RNA Silencing
The natural maintenance cycles of many mosquito-borne viruses require establishment of persistent non-lethal infections in the invertebrate host. While the mechanisms by which this occurs are not well understood, antiviral responses directed by small RNAs are important in modulating the pathogenesis of viral infections in disease vector mosquitoes. In yet another example of an evolutionary arms...
متن کاملGene silencing without DNA. rna-mediated cross-protection between viruses
Previously, it was shown that the upper leaves of plants infected with nepoviruses and caulimoviruses are symptom free and contain reduced levels of virus. These leaves are said to be recovered. Recovery is associated with RNA-mediated cross-protection against secondary virus infection. Here, by analyzing plants infected with viruses that are quite distinct from the nepovirus or caulimovirus gr...
متن کاملRNA silencing
RNA silencing is a newly discovered mechanism of genetic regulation in eukaryotes. It is based on an immune system that protects eukaryotes against viruses and transposons and in some respects it is conceptually similar to classical humoral immunity. However RNA silencing is distinct from humoral immunity in that it only targets nucleic acids and has a specificity mechanism based on nucleic aci...
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ژورنال
عنوان ژورنال: Uirusu
سال: 2008
ISSN: 0042-6857
DOI: 10.2222/jsv.58.61